Researchers at Leipzig University have developed a new process for reversing the polarity of chemical compounds, also known as umpolung, for the precise synthesis of pharmaceuticals. This innovative method, developed by a team of scientists led by Professor Christoph Schneider at the Institute of Organic Chemistry, provides a solution-oriented approach to a long-standing challenge in organic and medicinal chemistry,” says Till Friedmann, lead author of the study funded by the German Research Foundation. It has just been published in the prestigious Journal of the American Chemical Society.