Researchers led by Javier Montenegro at CiQUS have shown that alternating cycles of light and darkness can steer the self-organization of dynamic molecular systems towards more stable architectures. The study reveals that periods of darkness play an active role in the evolution of photoresponsive molecules, enabling them to reach structural states inaccessible under continuous illumination.

An investigational drug called davunetide, sprayed into the nose, reaches the brain in different amounts depending on biological sex and, in females, on the phase of the reproductive cycle. Working in mice and then in a small group of healthy adults, researchers at Tel Aviv University found that female mice took up more drug into the head region when estrogen was highest, during proestrus and estrus. In people, women trended toward higher peak plasma concentrations while men held the drug longer. The authors argue that averaging across sexes can hide a real drug effect, and that timing and hormones belong at the center of how brain therapies are designed and dosed.

Researchers at the University of Osaka have developed a quantum mechanical model for concentrated organic radical solutions considering stochastic collisions between molecules. The first-order contribution to intermolecular interactions is averaged to zero by collisional fluctuations, but the second-order term survives and enhances the magnetic susceptibility. These results explain experimental observations of an anomalous increase in the magnetic susceptibility at the solid-to-fluid transition that cannot be predicted by conventional theories.