A research group led by The University of Osaka has discovered that the DNA repair enzyme Polβ plays a crucial role in protecting the developing brain from harmful mutations. The study found that a lack of Polβ leads to a significant increase in small insertions and deletions of DNA, known as indels near CpG sites, which are important regulatory regions in genes. This accumulation of mutations could contribute to neurodevelopmental disorders.

The health-related needs of an ageing population, bio-tech innovations, leveraging health data, ethics and AI in healthcare, nurturing start-ups, and investor insights—these are just a few of the topics to be featured at Digital Health Asia 2025 (DHA) from 8 to 10 September at City University of Hong Kong.

KAIST (President Kwang Hyung Lee) announced that a joint research team—led by Professor Seung-Jae V. Lee of the Department of Biological Sciences at KAIST and the Research Center for RNA-mediated Healthy Longevity, Professor Jinsoo Seo of Yonsei University (President Dong-Sup Yoon), and Professor Kwang-Pyo Lee of the Korea Research Institute of Bioscience and Biotechnology (KRIBB, President Suk Yoon Kwon) under the National Research Council of Science & Technology (NST, Chairman Yeung-Shik Kim—has discovered that the protein ‘PELOTA*’, which plays a key role in ribosome-associated quality control, regulates the pace of aging.

Australian researchers have created the first detailed molecular map of the human bone marrow, revealing new insights that could reshape our thinking about how an incurable blood cancer grows and spreads.

 

A study of 4,257 pneumonia patients identified three clinical phenotypes with distinct outcomes. The use of 80mg equivalent intravenous methylprednisolone treatment can reduce patient mortality in phenotype C. Precision treatment based on phenotypes could optimize therapy.