Living brain tissue reveals 80% of genes behave differently than assumed
Reports and Proceedings
Updates every hour. Last Updated: 2-Jan-2026 05:11 ET (2-Jan-2026 10:11 GMT/UTC)
In a new Genomic Press Interview, Dr. Alexander W. Charney shares how collecting brain tissue from living neurosurgery patients revealed that 80% of genes show different expression than in postmortem samples. His Living Brain Project challenges decades of neuroscience assumptions while advancing personalized medicine approaches for schizophrenia and severe mental illness.
A group of researchers led by The University of Osaka have identified a novel genetic mutation in Streptococcus pyogenes, a common bacterium which causes strep throat, significantly associated with severe invasive infections. A single mutation in the bacterial ferric ion transporter enhances bacterial growth in human blood. This mutation, unique to Japanese isolates, indicates a novel pathogenic mechanism. This world-first discovery offers a potential new target for treatments and preventive measures.
Regular walking is widely recognized for its significant benefits to overall health and well-being. Previous research has primarily focused on middle-to-high-income White populations. Now, a novel analysis using data from the Southern Community Cohort Study, involving 79,856 predominantly low-income and Black individuals across 12 southeastern US states, confirms the benefits of regular walking, especially at a faster pace, within a crucial, underrepresented group. The new study appearing in the American Journal of Preventive Medicine, published by Elsevier, underscores the importance of promoting walking, particularly at a brisk pace, as an effective form of physical activity for improving health.
A new study from a USC research team just published in Nature Communications reveals major insights in understanding how the human spinal cord triggers the bladder emptying process – insights that could lead to new therapies to help patients regain control of this essential function. For the study researchers from USC Viterbi School of Engineering and Keck School of Medicine of USC harnessed functional ultrasound imaging (fUSI), an emerging neuroimaging technology that is minimally invasive, to observe real-time changes in blood flow dynamics in the human spinal cord during bladder filling and emptying. Because the fUSI process requires a “window” through the bone to work, researchers worked with a group of patients undergoing standard-of-care epidural spinal cord stimulation surgery for chronic low back pain to measure where changes in blood volume occur on the spinal cord during the cycle of urination. During the implantation of the stimulator, researchers were able to use the window created in the bone to safely insert leads to image the spinal cord using fUSI. While the patient was under anesthesia, the team gathered the fUSI imaging data of the spinal cord while gently filling and emptying the bladder with saline to simulate a full urination cycle. The experiments identified that some spinal cord regions showed positive correlation, meaning their activity increased as bladder pressure rose, while others showed negative (anti-correlation), with activity decreasing as pressure increased. This suggests the involvement of both excitatory and inhibitory spinal cord networks in bladder control. This study offers a tangible path toward addressing this critical need for patients suffering from neurogenic lower urinary tract dysfunction. The ability to decode bladder pressure from spinal cord activity provides proof-of-concept for developing personalized spinal cord interfaces that could warn patients about their bladder state, helping them regain control.
Childhood brain tumor survival depends on the type of tumor. Comparing survival rates across countries is difficult, because brain tumors aren’t recorded in the same way everywhere in Europe. A new study led by the Princess Máxima Center is helping to change that. For the first time, the research provides a clear and clinically relevant overview of survival outcomes for children with brain tumors.