Pennington Biomedical highlights how cellular quality control contribute to insulin resistance related to type 2 diabetes
Peer-Reviewed Publication
Updates every hour. Last Updated: 29-Oct-2025 15:11 ET (29-Oct-2025 19:11 GMT/UTC)
Researchers at Pennington Biomedical Research Center have revealed critical insights into how impaired mitochondrial dynamics and quality control mechanisms in skeletal muscle influence insulin sensitivity in patients with Type 2 Diabetes, or T2D. The study, titled "Deubiquitinating Enzymes Regulate Skeletal Muscle Mitochondrial Quality Control and Insulin Sensitivity in Patients with Type 2 Diabetes," was recently published in the Journal of Cachexia, Sarcopenia and Muscle.
The research team, led by Pennington Biomedical Executive Director Dr. John Kirwan, focused on the significance of deubiquitinating enzymes, or DUBs, in regulating mitochondrial dynamics within skeletal muscle. Findings suggest that mitochondrial fragmentation can bypass defects in mitophagy, the process by which cells remove damaged mitochondria, to sustain skeletal muscle quality control in patients with T2D. This adaptation may help maintain mitochondrial function despite impaired mitophagy.
Despite decades of public health messaging, Canadians are spending more time in the sun and using less sun protection – raising alarms among researchers as melanoma cases continue to climb.
That trend is highlighted in a McGill University-led study that analyzed national survey data collected between 2011 and 2018 from over 77,000 people, representing a weighted sample of 21 million Canadians.
NRG Oncology (NRG), a National Cancer Institute (NCI) National Clinical Trials Network (NCTN) group focused on improving outcomes for adults with cancer through multi-center clinical research, recently announced it added two new Chairs to the organization’s Lung Cancer Committee and Imaging Committee.
The BCG vaccine protects against tuberculosis, but by inducing trained immunity it also protects against many more respiratory infections. International research led by the Radboudumc shows how this process works. Lactate, a product of scaled-up energy production, appears to play a leading role.
Researchers at Sutter Health, led by Cheryl Stults, Ph.D., found that an innovative ambient artificial intelligence platform showed promising results in easing the burden of clinical documentation for healthcare providers. The study, published today in JAMA Network Open, revealed significant reductions in documentation time and improved overall clinician satisfaction. It also highlights the technology’s potential to address long-standing challenges in the medical profession.