A new clinical trial led by the Alliance for Clinical Trials in Oncology will investigate if a combination of drug therapies after radiation therapy improves outcomes for people with newly-diagnosed, grade 3 IDH-mutant astrocytoma, a type of brain cancer. Supported in part by a grant from the National Cancer Institute, the study (Alliance A072301) will look at whether adding the oral medication vorasidenib to the standard oral chemotherapy can help keep the cancer from coming back after radiation.

Measuring high aspect ratio and composite micro-trenches without damage is critical for advanced microfabrication, yet conventional coherence scanning interferometry often suffers from a low signal-to-noise ratio and limited lateral resolution. A team from Nanjing University of Science and Technology presents FP-CSI, a transmissive near-infrared interferometric modality that combines aperture synthesis from Fourier ptychographic microscopy with quantitative phase recovery of coherence scanning interferometry, enabling robust 3D morphology reconstruction without iterative phase retrieval.

Tendon-sheath mechanisms help robots work in confined and tortuous spaces, but friction inside these cable-like transmissions can distort motion and make accurate control difficult. Scientists at Nanjing University of Aeronautics and Astronautics identify why many existing control strategies fall short in practice and propose a more compact, adaptable solution based on accumulated curve angle sensing and feedforward compensation.

An extensive computational study by researchers from the University of Jyväskylä (Finland) predicted that gold nanoclusters could selectively recognize chiral biomolecules. This property may help in detecting certain diseases directly from a blood sample.

Osaka Metropolitan University researchers developed a DDS that specifically transports Paclitaxel (PTX), a relatively large and poorly water-soluble anticancer drug, to cancerous tissue. They utilized the L-PGDS enzyme as a novel DDS carrier to efficiently transport PTX.

- Research team led by Jae Eun Jang and Goeun Pyo demonstrates stable “dual-modulated vertically stacked transistors” even with two-dimensional nanochannels - Enables large-area and multilayer scalability without costly ultra-precision fabrication processes, which is promising for high-density 3D chips and flexible devices - Published in the leading international journal Advanced Science