We systematically review 34 relevant studies between 2015 and 2025 following the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines, focusing on the combination of multimodal wearable sensing with learning models.

A collaborative research team from the National Institute for Fusion Science (NIFS), the University of Tokyo, Kyushu University, and Brookhaven National Laboratory has, for the first time, directly and precisely measured changes in the internal electric potential of a fusion plasma under conditions similar to those expected in fusion reactors.

 

This achievement establishes a new method for in situ evaluation of plasma confinement states, providing key insights for the control and performance optimization of next-generation fusion reactors. The internal plasma potential plays a crucial role in determining how effectively energy is confined within the plasma. By combining advanced accelerator technology with non-contact plasma diagnostics, the researchers have opened a new path toward direct understanding of the behavior of fusion-core plasmas.

The growing prevalence of exercise-induced tibial stress fractures demands wearable sensors capable of monitoring dynamic musculoskeletal loads with medical-grade precision. While flexible pressure-sensing insoles show clinical potential, their development has been hindered by the intrinsic trade-off between high sensitivity and full-range linearity (R² > 0.99 up to 1 MPa) in conventional designs. Inspired by the tactile sensing mechanism of human skin, where dermal stratification enables wide-range pressure adaptation and ion-channel-regulated signaling maintains linear electrical responses, we developed a dual-mechanism flexible iontronic pressure sensor (FIPS). This innovative design synergistically combines two bioinspired components: interdigitated fabric microstructures enabling pressure-proportional contact area expansion (∝ P^1/3) and iontronic film facilitating self-adaptive ion concentration modulation (∝ P^2/3), which together generate a linear capacitance-pressure response (C ∝ P). The FIPS achieves breakthrough performance: 242 kPa⁻¹ sensitivity with 0.997 linearity across 0–1 MPa, yielding a record linear sensing factor (LSF = 242,000). The design is validated across various substrates and ionic materials, demonstrating its versatility. Finally, the FIPS-driven design enables a smart insole demonstrating 1.8% error in tibial load assessment during gait analysis, outperforming nonlinear counterparts (6.5% error) in early fracture-risk prediction. The biomimetic design framework establishes a universal approach for developing high-performance linear sensors, establishing generalized principles for medical-grade wearable devices.

Emerging ferroptosis–immunotherapy strategies, integrating functionalized nanoplatforms with ferroptosis-inducing agents and immunomodulatory therapeutics, demonstrate significant potential in managing primary, recurrent, and metastatic malignancies. Mechanistically, ferroptosis induction not only directly eliminates tumor cells but also promotes immunogenic cell death (ICD), eliciting damage-associated molecular patterns (DAMPs) release to activate partial antitumor immunity. However, standalone ferroptosis therapy fails to initiate robust systemic antitumor immune responses due to inherent limitations: low tumor immunogenicity, immunosuppressive microenvironment constraints, and tumor microenvironment (TME)-associated physiological barriers (e.g., hypoxia, dense extracellular matrix). To address these challenges, synergistic approaches have been developed to enhance immune cell infiltration and reestablish immunosurveillance, encompassing (1) direct amplification of antitumor immunity, (2) disruption of immunosuppressive tumor niches, and (3) biophysical hallmark remodeling in TME. Rational nanocarrier design has emerged as a critical enabler for overcoming biological delivery barriers and optimizing therapeutic efficacy. Unlike prior studies solely addressing ferroptosis or nanotechnology in tumor therapy, this work first systematically outlines the synergistic potential of nanoparticles in combined ferroptosis–immunotherapy strategies. It advances multidimensional nanoplatform design principles for material selection, structural configuration, physicochemical modulation, multifunctional integration, and artificial intelligence-enabled design, providing a scientific basis for efficacy optimization. Moreover, it examines translational challenges of ferroptosis–immunotherapy nanoplatforms across preclinical and clinical stages, proposing actionable solutions while envisioning future onco-immunotherapy directions. Collectively, it provides systematic insights into advanced nanomaterial design principles and therapeutic optimization strategies, offering a roadmap for accelerating clinical translation in onco-immunotherapy research.

Researchers in China have developed an advanced biochar-based material that dramatically improves the removal of harmful nitrate nitrogen from agricultural soils and water, offering promising new avenues for sustainable farming and environmental protection. The study, led by Dr. Lan Luo with colleagues from the Chinese Academy of Agricultural Sciences, explores how biochar loaded with nanoscale zero-valent iron (nZVI) can mitigate nitrogen leaching, a major contributor to groundwater contamination and soil degradation.