This article explores a new therapeutic approach for rheumatoid arthritis (RA) using a combination of triptolide and medicarpin. Recent research published in Engineering reveals that targeting the m⁶A methylation pathway can significantly reduce bone destruction associated with RA. The study demonstrates that the combined use of triptolide and medicarpin effectively inhibits osteoclastogenesis and modulates inflammation, offering a potential strategy to improve treatment outcomes and minimize side effects in RA patients.

This article introduces a new methodology for predicting the service life of concrete structures in marine environments, published in Engineering. Researchers from Southeast University have developed a multiscale modeling approach combined with extensive data analysis to efficiently assess the durability of marine concrete structures. By leveraging numerical simulations and real-world datasets, the study offers a more efficient alternative to traditional long-term exposure testing, providing valuable insights for the design and maintenance of concrete structures in marine conditions.

International tech community to assess 20 years of using digital technologies for progress and chart future direction ahead of UN General Assembly review

In a step toward treating mitochondrial diseases, researchers in the Netherlands have successfully edited harmful mutations in mitochondrial DNA using a genetic tool known as a base editor. The results, published June 24^th in the open-access journal PLOS Biology, offer new hope for people with rare genetic conditions.