This study published in Engineering offers new insights into the impact of alcoholic liver disease (ALD) on post-transplant outcomes in patients with hepatocellular carcinoma (HCC) and hepatitis B virus (HBV) infection. Researchers found that ALD significantly increases the risk of HBV reactivation and worsens survival outcomes following liver transplantation. Using advanced machine learning techniques, the study identified key metabolic factors associated with HBV reactivation and developed a novel risk stratification index to better predict patient outcomes. The findings highlight the importance of considering ALD in the management of liver transplant recipients with HBV-related HCC.

The ingredient, extracted from the plant’s seeds, is a good source of protein and has a neutral flavor and aroma, making it easy to use in food products.

A multinational team of researchers, co-led by the Garvan Institute of Medical Research, has developed and tested a new AI tool to better characterise the diversity of individual cells within tumours, opening doors for more targeted therapies for patients.

Two Purdue University researchers have received $50,000 apiece to develop their innovations in the fields of cancer treatments and freshwater management. The funding comes from the Trask Innovation Fund, managed by Purdue Innovates Incubator. The fund supports Purdue researchers through the “valley of death," the time to move an innovation from laboratory creation to marketplace product.

RNAi technologies have been exploited to control viruses, pests, oomycetes and fungal phytopathogens that cause disasters in host plants, including many agronomically significant crops. However, it is unclear what process mediates RNA uptake by fungi. Here, the authors utilized live-cell imaging technology combined with molecular biology experiments to demonstrate that exogenous RNA is indiscriminately absorbed by Verticillium dahliae, the notorious plant pathogenic fungus. The uptake of exogenous RNA by fungal cells is predominantly mediated through endocytosis. This study not only provides a new theoretical foundation for applying trans-kingdom RNA interference technology in crop protection but also lays the groundwork for research and applications of exogenous RNA in plant-fungi interaction systems.