AI-guided protein design for enhanced intracellular antibodies
Peer-Reviewed Publication
Updates every hour. Last Updated: 3-Apr-2026 09:15 ET (3-Apr-2026 13:15 GMT/UTC)
A new artificial intelligence-driven pipeline developed in a collaborative research combines protein structure prediction, sequence design, and live-cell screening together to enable rapid conversion of antibody sequences into functional intracellular antibodies (intrabodies) that are stable within living cells. By preserving antigen-binding regions and improving structural stability, the approach overcomes major barriers encountered in intrabody development—emerging as a simpler, more cost-effective tool for diagnostics, imaging, and biomedical research.
Cooperation exists in board games, among researchers and among bacteria. Working closely together locally, scientists have deciphered how two species of bacteria join forces to avoid being eaten.
A team from the Universitat Politècnica de València and the company Corify Care has made a major breakthrough in cardiac electrophysiology with the publication of its patented Global Volumetric Mapping technology in the journal Nature Communications Medicine. The publication validates the first system capable of simultaneously mapping all four chambers of the heart, providing physicians with a comprehensive, real-time view of arrhythmias that current solutions cannot offer.
To lower agricultural emissions, policymakers and communities first need to pinpoint the sources. Not just by country but crop by crop, field by field. In a Cornell Unviersity study published Feb. 13 in Nature Climate Change, researchers have synthesized data from multiple ground sources and models to map global cropland emissions at high resolution – down to about 10 kilometers – while breaking down emissions by crop and source and identifying regions for more precise mitigation.