The low endosomal escape efficiency of endocytosis-based delivery has become a key barrier restricting therapeutic biomacromolecule applications in biomedicine. A review published in Biomedical Analysis highlights emerging non-endocytic transmembrane delivery strategies that bypass conventional cellular uptake pathways and enable direct cytosolic delivery of proteins, nucleic acids, and gene-editing tools. Led by Dr. Yang Liu from Hefei Comprehensive National Science Center, the review summarizes recent advances in physical, biomimetic, and bioengineered delivery platforms and discusses their potential for gene therapy, drug delivery, and cellular engineering.

With the expansion of sustainable investments, understanding how green financial assets interact has become increasingly important. A quantile analysis of market data, under different market situations, revealed that green cryptocurrencies, particularly Cardano and Stellar, often act as major transmitters of risk, while traditional green assets tend to absorb rather than mitigate market shocks. This study highlights the evolving nature of risk management within sustainable finance.

T-cell engagers (TCEs) are an emerging class of immunotherapeutics that have demonstrated considerable clinical efficacy across a range of tumor types. However, their clinical application remains constrained by the challenge of balancing antitumor activity with acceptable safety, which is particularly prominent in solid malignancies. Multiple strategies have been explored to address this trade-off, including molecular engineering, dosing regimens, and patient selection. Nonetheless, within molecular design efforts, activity and toxicity are still largely optimized in isolation.

Despite the ultra-high theoretical capacity of silicon (Si) anodes, their practical application is severely hindered by drastic volume effect and an unstable solid-electrolyte interphase (SEI). Atomic/molecular layer deposition (ALD/MLD) technology exhibits unique advantages in mitigating these challenges by constructing a stable and functionalized interface on Si anodes. This review summarizes recent advances and presents perspectives on ALD/MLD for Si anode interface engineering. Firstly, the existing interfacial challenges are analyzed: mechanical failure and structural degradation, complex/unstable SEI, and insufficient interfacial charge transfer. Subsequently, the key role and mechanism of ALD/MLD in enhancing the performance of Si anodes are elucidated from an atomic/molecular-scale interface engineering perspective. Crucially, three key aspects are emphasized: enhancing structural stability through mechanical confinement and stress dissipation, inducing the formation of stable SEI via ingenious interface chemical design, and constructing efficient ion/electron transport channels to optimize interfacial charge transfer kinetics. Finally, future research directions on ALD/MLD for Si anode interface engineering are proposed.

AI4S in Educational Research, edited by Professor Chen Xiangdong from the Department of Education Information Technology at the Faculty of Education, East China Normal University, presents a core research finding of the Chinese Association for Artificial Intelligence (CAAI). The book systematically constructs a theoretical and practical framework for AI4S-empowered educational research, providing essential academic guidance and actionable references for educational researchers and administrators.

Reported in Science Bulletin, a new study presents the design and fabrication of an ultra-robust and multifunctional ionic biogel with multiscale architecture via a synergistic structural engineering strategy, and demonstrates its application in self-powered human interaction.

Researchers have developed a green separation process combining a tailor-made ionic liquid with heat pump technology that slashes energy consumption by 48.68% for separating dimethyl carbonate from methanol—a critical bottleneck in sustainable chemical production. Using a multi-scale strategy spanning molecular screening, experimental validation, and process optimization, the team identified an eco-friendly ionic liquid entrainer that breaks the stubborn azeotrope between these industrially important chemicals, paving the way for more sustainable and cost-effective manufacturing.