Evolving trends and drug class dynamics in drug-induced fatty liver disease over two decades
Peer-Reviewed Publication
Updates every hour. Last Updated: 25-Dec-2025 09:11 ET (25-Dec-2025 14:11 GMT/UTC)
This study analyzes 20 years of data from the Food and Drug Administration’s Adverse Event Reporting System (FAERS) to reveal trends in drug-induced fatty liver disease (DIFLD), identifying high-risk drug classes and vulnerable populations, and highlighting the need for region-specific pharmacovigilance and tailored interventions.
Perfluoroalkyl substances (PFASs) refer to a group of man-made chemicals that are widely used due to their water- and stain-resistant properties and exceptional chemical stability. However, they often accumulate in the environment, causing environmental and health hazards. A team of researchers has recently shown how zinc oxide nanocrystals capped with specific ligands can efficiently defluorinate perfluorooctanesulfonic acid, a well-known perfluoroalkyl substance. This approach could solve PFAS recycling challenges.
Tin monosulfide (SnS) is a promising, earth-abundant material for thin-film solar cells, but device performance has long been limited by defects and unwanted reactions at the rear contact interface. Now, researchers from Korea demonstrate that inserting an ultra-thin germanium oxide layer between the molybdenum back contact and SnS region mitigates these issues. Their findings highlight how interface engineering can greatly boost power conversion efficiency, paving the way for improving performance in many such electronics and energy technologies.
Seabirds in one of the remotest parts of the planet are being exposed to a wide range of forever chemicals, scientists have discovered.
Researchers have found ‘forever chemical’ compounds in seabirds from the remote Southern Ocean - providing further evidence highlighting the global reach of per- and polyfluoroalkyl substances (PFAS), known as forever chemicals because they do not easily break down in the environment.
The researchers focused on the structure and dynamics of kinetoplast DNA, the mitochondrial genome of Trypanosomes, with an experimental study led by Edinburgh and a computational analysis that involved simulations conducted by UniTrento. Trypanosomes are a family of parasites (flagellated protozoa) that pose a risk to humans and animals because they are responsible for a number of tropical diseases, such as leishmaniasis and sleeping sickness, which are transmitted by the bite of flies, mosquitoes or other insects.
Quantifying the spatial organization and dynamics of the different regions of the mitochondrial genome of this blood parasite is a major challenge in biology. And this particular genome stands out for characteristics that can be useful for the development of new materials.