22-May-2025
Researchers develop gene therapy that can target airway and lungs via nasal spray
Mass General BrighamPeer-Reviewed Publication
For gene therapy to work well, therapeutic molecules need to be efficiently delivered to the correct locations in the body—a job commonly given to adeno-associated viruses (AAV).
To improve the AAV’s ability to deliver therapeutics specifically to the lungs and airway, Mass General Brigham researchers developed and applied a new version, called AAV.CPP.16, that can be administered with a nasal spray. In preclinical models, the innovative tool outperformed previous versions by more effectively targeting the airway and lungs and showing promise for respiratory and lung gene therapy. Results are published in Cell Reports Medicine.
- Journal
- Cell Reports Medicine
- Funder
- Brigham and Women’s Hospital sundry fund, National Natural Science Foundation of China, Natural Science Foundation of Jiangsu Province, National Basic Science Center Program of China, Basic Research Program of Yunnan Province, NHC Key Laboratory of Drug Addiction Medicine