Targeting collagen signaling boosts drug delivery in pancreatic cancer
Peer-Reviewed Publication
Updates every hour. Last Updated: 6-Apr-2026 11:16 ET (6-Apr-2026 15:16 GMT/UTC)
Researchers from Okayama University and Tohoku University have discovered that targeting collagen signaling through the discoidin domain receptor 1 (DDR1) enhances drug delivery and reverses therapy-induced resistance in pancreatic cancer. Their study shows that DDR1 inhibition improves macromolecular drug penetration and mitigates fibrosis triggered by MEK inhibitors, offering new hope for more effective treatment strategies.
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