Engineering smart delivery for gene editors
Peer-Reviewed Publication
Updates every hour. Last Updated: 20-Aug-2025 05:10 ET (20-Aug-2025 09:10 GMT/UTC)
A research team from Helmholtz Munich and the Technical University of Munich has developed an advanced delivery system that transports gene-editing tools based on the CRISPR/Cas9 gene-editing system into living cells with significantly greater efficiency than before. Their technology, ENVLPE, uses engineered non-infectious virus-like particles to precisely correct defective genes – demonstrated successfully in living mouse models that are blind due to a mutation. This system also holds promise for advancing cancer therapy by enabling precise genetic manipulation of engineered immune cells making them more universally compatible and thus more accessible for a larger group of cancer patients.
Could it be that one of only three known markers directly targeting the DNA does not exist outside the realm of microbes? Now, researchers led by Xiaoqi Feng at the Institute of Science and Technology Austria (ISTA) have demonstrated that this marker—N4-methylcytosine (4mC)—is essential for sperm development and maturation in the liverwort Marchantia polymorpha, a key organism in plant evolution. The findings were published in Cell.
Northwestern University researchers have developed the first wearable device for measuring gases emitted from and absorbed by the skin. By analyzing these gases, the device offers an entirely new way to assess skin health, including monitoring wounds, detecting skin infections, tracking hydration levels, quantifying exposure to harmful environmental chemicals and more.