Researchers at Lehigh University have received a $2 million grant from the National Science Foundation to explore how biological computation could make artificial intelligence (AI) more energy-efficient and powerful. The team, led by Yevgeny Berdichevsky, associate professor of bioengineering and electrical and computer engineering, will study neurons within engineered brain organoids—three-dimensional structures grown from adult stem cells that resemble developing brain tissue. By arranging and stimulating neurons in controlled ways, the researchers aim to replicate how the brain processes dynamic information, such as moving images. The interdisciplinary project combines neuroscience, bioengineering, electrical engineering, and computer science to create a proof of concept for biological computation and to inspire new AI algorithms. The researchers will also assess the ethical, social, and legal considerations of using brain organoids in computation.