The precise mechanism of cellular condensation and regeneration is not well-understood in organogenesis. For advances in regenerative medicine, understanding these mechanisms is crucial. In a new study, researchers used single-cell transcriptomics to understand the composition of human dental follicles and dental papillae. They found a PDGFRA⁺ mesenchymal stem cell with odontogenic potential that interacts with endothelial cells via paracrine signaling to stimulate angiogenesis, showing promise for future therapeutics in dental regenerative medicine.

Patients with microsatellite instability-high (MSI-H) tumors are likely to have better clinical outcomes than other patients. Recently, researchers from Yonsei University College of Medicine have proposed MSI-SEER, a novel AI model for accurate MSI prediction as well as immune checkpoint inhibitor responsiveness prediction. The innovative technology is expected to help battle gastric and colorectal cancers and further cancer research in general.

One of the best ways to protect artists’ creative work is to prevent it from ever being seen by “AI crawlers” – the programs that harvest data on the Internet for training generative models.  But most artists don’t have access to the tools that would allow them to take such actions.  And when they do have access, they don’t know how to use them. These are some of the conclusions of a study by a group of researchers at the University of California San Diego and University of Chicago, which will be presented at the 2025 Internet Measurement Conference in October in Madison, Wis.

A code-reuse attack named Coroutine Frame-Oriented Programming (CFOP) is capable of exploiting C++ coroutines across three major compilers, namely Clang/LLVM, GCC and MSVC. CFOP even succeeds in environments that are protected by Control Flow Integrity (CFI), exposing relevant gaps in 15 of these defense schemes. Rather than injecting new code, CFOP chains together existing functions, achieving arbitrary code execution after corrupting coroutine-internal memory structures. This new exploitation technique has been discovered by researchers at the CISPA Helmholtz Center for Information Security, who have been the first to study C++ coroutines from a security perspective. To mitigate CFOP, they propose structural changes to the ways in which C++ coroutines are implemented by major compilers.