For decades, scientists struggled to pin down which gene is responsible for the heart problems that are so common among babies born with Down syndrome. Now, scientists at Gladstone Institutes have an answer. In a study published in Nature, the researchers leveraged stem cell science and artificial intelligence to discover that a gene called HMGN1 disrupts how DNA is packaged and regulated, and can throw off levels of hundreds of other molecules involved in healthy heart development.

Soil freeze–thaw (FT) cycles play a crucial role in land–atmosphere energy exchange and climate regulation, yet accurate global detection remains challenging. 

In International Journal of Extreme Manufacturing, researchers have developed a dual post-processing method to make 3D-printed metals much stronger and tougher, addressing one of the field’s most persistent challenges.

A historian explores how a little-known Illinois company, the Americana Corporation, helped shape the modern nursing home in postwar America. Her research shows how architecture was central to this shift, not just housing older adults but creating an entire system of care. By examining the physical and institutional design of Americana’s homes, she uncovers how midcentury ideals around aging, medicine and profit became embedded in the built environment – a legacy that continues to define long-term care today.