Researchers have improved the ability of wearable health devices to accurately detect when a patient is coughing, making it easier to monitor chronic health conditions and predict health risks such as asthma attacks. The advance is significant because cough-detection technologies have historically struggled to distinguish the sound of coughing from the sound of speech and nonverbal human noises.

In a paper published in SCIENCE CHINA Earth Sciences, the researchers combined Eulerian and Lagrangian methods to more accurately quantify surface eddy meridional heat transport (EHT) induced by both the stirring and trapping effects of mesoscale eddies. They find that stirring-induced surface EHT is 1–2 orders of magnitude larger than trapping-induced EHT throughout most of the global ocean. These results demonstrate that the horizontal stirring effect of mesoscale eddies is the dominant mechanism of EHT.

According to a study by the Department of Physics and the Institute of Environmental Science and Technology of the Universitat Autònoma de Barcelona (ICTA-UAB), the Mar Menor saltwater lagoon in Murcia, Spain, the largest in Europe, contains sediments with levels of lead, arsenic, zinc, mercury, copper, and silver that exceed toxicity thresholds and values reported for similar coastal ecosystems worldwide.  

Hutchinson-Gilford progeria syndrome (HGPS) is a rare premature aging disease, and approximately 90% of cases are caused by progerin. Progerin is toxic and causes diverse abnormalities. More and more studies show that progerin is also detected in physiological aging and chronic kidney disease (CKD). Thus, targeting progerin clearance shows powerful potential for the treatment of HGPS, CKD and aging-related diseases. Now, Zhang group from Peking University and Kunming University of Science and Technology, reports that activating lysosome biogenesis can promote progerin clearance and alleviate cellular senescence in HGPS. They identify lysosome defects as a prevalent feature in HGPS, which impairs progerin clearance, and reveal that activating lysosome biogenesis can counteract lysosome defects and accelerate progerin clearance and mitigate DNA damage, cell cycle arrest, low proliferation ability and senescence-associated secretory phenotype (SASP) in HGPS cells. The findings highlight the vital role of lysosomes in progerin clearance, and uncover the potential of targeting lysosome biogenesis in anti-senescence.