Researchers create ‘virtual scientists’ to solve complex biological problems
Peer-Reviewed Publication
Updates every hour. Last Updated: 20-Aug-2025 17:09 ET (20-Aug-2025 21:09 GMT/UTC)
A group of researchers led by The University of Osaka have identified a novel genetic mutation in Streptococcus pyogenes, a common bacterium which causes strep throat, significantly associated with severe invasive infections. A single mutation in the bacterial ferric ion transporter enhances bacterial growth in human blood. This mutation, unique to Japanese isolates, indicates a novel pathogenic mechanism. This world-first discovery offers a potential new target for treatments and preventive measures.
Thermoelectric materials, capable of direct conversion between thermal and electrical energy, have garnered significant attention for their potential in energy recovery and microelectronic power supply. Among various thermoelectric material systems, binary indium chalcogenides (In-X, X = Te, Se, S) stand out due to their exceptionally low thermal conductivity. On June 10, 2024, Professor Yang Jiong's team at Shanghai University published a Review titled “Structural Characteristics and Recent Advances in Thermoelectric Binary Indium Chalcogenides” in Research (DOI: 10.34133/research.0727). The work systematically analyzes the crystal structure features of binary indium chalcogenides, employs first-principles calculations to reveal their electronic band and phonon dispersion, and discusses the influence of unconventional chemical bonds (e.g., In-In bonds) and mixed valence states on electronic structure and lattice vibrations, elucidating potential physical mechanisms behind their low thermal conductivity. The review also summarizes experimental optimization strategies such as defect engineering, crystal orientation engineering, nano-structuring, and grain size engineering, with a focus on synergistic optimization of electrical and thermal transport properties through doping and vacancy modulation. Additionally, the work outlines major challenges and future directions for binary indium chalcogenides in thermoelectric applications, providing critical guidance for designing high-performance thermoelectric materials.
A new study from a USC research team just published in Nature Communications reveals major insights in understanding how the human spinal cord triggers the bladder emptying process – insights that could lead to new therapies to help patients regain control of this essential function. For the study researchers from USC Viterbi School of Engineering and Keck School of Medicine of USC harnessed functional ultrasound imaging (fUSI), an emerging neuroimaging technology that is minimally invasive, to observe real-time changes in blood flow dynamics in the human spinal cord during bladder filling and emptying. Because the fUSI process requires a “window” through the bone to work, researchers worked with a group of patients undergoing standard-of-care epidural spinal cord stimulation surgery for chronic low back pain to measure where changes in blood volume occur on the spinal cord during the cycle of urination. During the implantation of the stimulator, researchers were able to use the window created in the bone to safely insert leads to image the spinal cord using fUSI. While the patient was under anesthesia, the team gathered the fUSI imaging data of the spinal cord while gently filling and emptying the bladder with saline to simulate a full urination cycle. The experiments identified that some spinal cord regions showed positive correlation, meaning their activity increased as bladder pressure rose, while others showed negative (anti-correlation), with activity decreasing as pressure increased. This suggests the involvement of both excitatory and inhibitory spinal cord networks in bladder control. This study offers a tangible path toward addressing this critical need for patients suffering from neurogenic lower urinary tract dysfunction. The ability to decode bladder pressure from spinal cord activity provides proof-of-concept for developing personalized spinal cord interfaces that could warn patients about their bladder state, helping them regain control.