Free fatty acids induce mammary epithelial cell death in ketotic dairy cows via endoplasmic reticulum stress
Peer-Reviewed Publication
Updates every hour. Last Updated: 11-May-2026 16:16 ET (11-May-2026 20:16 GMT/UTC)
High concentrations of free fatty acid (FFA) in ketotic dairy cows activate endoplasmic reticulum (ER) stress pathways, contributing to mammary epithelial cell apoptosis and reduced milk yield. The study sets the stage for in vivo trials to validate ER stress inhibitors like Tauroursodeoxycholate (TUDCA) as practical solutions for managing ketosis and enhancing dairy cows health.
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