Article Highlights
Updates every hour. Last Updated: 12-May-2026 05:16 ET (12-May-2026 09:16 GMT/UTC)
Engineered probiotics emerge as programmable living medicines for complex diseases
Nanjing Agricultural University The Academy of Science- Journal
- BioDesign Research
Engineered RNA sensor detects and fights coronavirus inside living cells
Nanjing Agricultural University The Academy of Science- Journal
- BioDesign Research
Discovery, characterization, and application of chromosomal integration sites in the hyperthermophilic archaeon Sulfolobus islandicus
University of Illinois at Urbana-Champaign Institute for Sustainability, Energy, and EnvironmentSulfolobus islandicus, an archaeal model organism, offers unique advantages for metabolic engineering and synthetic biology applications owing to its ability to thrive under low pH and high temperature conditions. Although several genetic tools exist for this organism, the absence of well-defined chromosomal integration sites continues to limit its development as a cellular factory. A research team at the University of Illinois Urbana-Champaign employed the CRISPR-COPIES pipeline and a multi-omics strategy that integrates genomics and epigenomics to guide the selection of genomic regions suitable for integration. This work expands the genetic toolbox for non-conventional hosts, advancing the potential for robust platforms for synthetic biology and industrial biotechnology.
- Journal
- Trends in Biotechnology
- Funder
- U.S. Department of Energy, National Research Foundation of Korea, Gordon and Betty Moore Foundation
Beyond species counts: scientists propose "trait-based" framework to predict biodiversity in a changing world
Biochar Editorial Office, Shenyang Agricultural UniversityA new perspective published in Biological Diversity links plant functional traits to ecological resilience, offering a more precise way to forecast how ecosystems will respond to climate change.
- Journal
- Biological Diversity
Achieving 20% toluene‑processed binary organic solar cells via secondary regulation of donor aggregation in sequential processing
Shanghai Jiao Tong University Journal CenterSequential processing (SqP) of the active layer offers independent optimization of the donor and acceptor with more targeted solvent design, which is considered the most promising strategy for achieving efficient organic solar cells (OSCs). In the SqP method, the favorable interpenetrating network seriously depends on the fine control of the bottom layer swelling. However, the choice of solvent(s) for both the donor and acceptor have been mostly based on a trial-and-error manner. A single solvent often cannot achieve sufficient yet not excessive swelling, which has long been a difficulty in the high efficient SqP OSCs. Herein, two new isomeric molecules are introduced to fine-tune the nucleation and crystallization dynamics that allows judicious control over the swelling of the bottom layer. The strong non-covalent interaction between the isomeric molecule and active materials provides an excellent driving force for optimize the swelling-process. Among them, the molecule with high dipole moment promotes earlier nucleation of the PM6 and provides extended time for crystallization during SqP, improving bulk morphology and vertical phase segregation. As a result, champion efficiencies of 17.38% and 20.00% (certified 19.70%) are achieved based on PM6/PYF-T-o (all-polymer) and PM6/BTP-eC9 devices casted by toluene solvent.
- Journal
- Nano-Micro Letters
Triple-functional hydrogel tackles resistant infections
Higher Education PressResearchers have developed an easy-to-apply antibacterial hydrogel by incorporating a biodegradable oligomer into a thermosensitive matrix. This hydrogel kills drug-resistant bacteria through a triple-action mechanism and demonstrates effective wound protection in biological models.
- Journal
- Pharmaceutical Science Advances
Escherichia albertii: The still unfolding journey of a misdiagnosed pathogen
Osaka Metropolitan University- Journal
- Microbiology and Molecular Biology Reviews
Bioinspired electrolyte‑gated organic synaptic transistors: From fundamental requirements to applications
Shanghai Jiao Tong University Journal CenterRapid development of artificial intelligence requires the implementation of hardware systems with bioinspired parallel information processing and presentation and energy efficiency. Electrolyte-gated organic transistors (EGOTs) offer significant advantages as neuromorphic devices due to their ultra-low operation voltages, minimal hardwired connectivity, and similar operation environment as electrophysiology. Meanwhile, ionic–electronic coupling and the relatively low elastic moduli of organic channel materials make EGOTs suitable for interfacing with biology. This review presents an overview of the device architectures based on organic electrochemical transistors and organic field-effect transistors. Furthermore, we review the requirements of low energy consumption and tunable synaptic plasticity of EGOTs in emulating biological synapses and how they are affected by the organic materials, electrolyte, architecture, and operation mechanism. In addition, we summarize the basic operation principle of biological sensory systems and the recent progress of EGOTs as a building block in artificial systems. Finally, the current challenges and future development of the organic neuromorphic devices are discussed.
- Journal
- Nano-Micro Letters