The rocks beneath our feet are leaving a hidden signature in the shells of marine snails along Australia’s ancient coastline, according to new research led by Adelaide University scientists.

In a single experiment, scientists can decipher the entire genomes of many patient samples, animal models or cultured cells. To fully realize the potential to study biology at this unprecedented scale, researchers must be equipped to analyze the titanic troves of data generated by these new methods.

Researchers at the MDI Biological Laboratory have identified how zebrafish regenerate and reconnect new kidney filtration units after injury, revealing a coordinated cellular process that allows newly formed nephrons to integrate into the kidney’s existing tubule network. The study, published in the journal Development, shows that specialized cells at the connection site briefly adopt invasive behaviors—extending protrusions that initiate the physical link between new and old structures—while neighboring cells simultaneously divide and expand the growing tubule. The work also identifies intersecting signaling pathways, including canonical and non-canonical branches of Wnt signaling mediated by the receptor fzd9b, that orient the connection and regulate cell behavior. Understanding how zebrafish achieve this precise integration may help researchers overcome a major obstacle in regenerative medicine: enabling lab-grown tissues and organoids to connect into existing organs and become fully functional.