Researchers at the Icahn School of Medicine at Mount Sinai have created the first comprehensive sex-specific atlas of GLP-1 expression in the mouse brain, mapping the molecule mimicked by blockbuster weight-loss drugs such as semaglutide at single-transcript resolution across 25 brain regions in each sex. Key hindbrain regions showed higher GLP-1 densities in females, while the olfactory bulb showed significantly greater expression in males, and several brain nuclei expressed the peptide in only one sex. These findings provide a neuroanatomical framework that may help explain why GLP-1 appears to exert stronger metabolic effects in females, with implications for the emerging psychiatric applications of GLP-1 analogs.

Retinal progenitor cells (RPCs) can differentiate into all major retinal cell types during development, but they permanently lose this capacity as one grows older, leaving the adult retina with no ability to regenerate lost neurons. Recently, researchers from Japan investigated the epigenetic mechanisms underlying this transition, identifying an enzyme called Setd8 as a key regulator of RPC identity. Their findings highlight a potential target for future regenerative therapies aimed at restoring lost vision.

An international research team led by Prof. Dr. Thomas Ott, professor at the University of Freiburg and member of the Cluster of Excellence CIBSS – Centre for Integrative Biological Signalling Studies, has demonstrated for the first time that the protein SYFO2, found in the roots of leguminous plants, makes it possible for the plants to ‘fertilize themselves’.

Herring from different parts of the Baltic Sea belong to distinct populations genetically adapted to local differences in salinity and temperature. However, these populations can also mix with each other, according to a new study by researchers from Uppsala University, Stockholm University and the Swedish University of Agricultural Sciences. These results have important implications for the management of the Baltic herring. The study is published in the Proceedings of the National Academy of Sciences.

Baylor University researchers have published a novel approach to fight colorectal cancer, using modified food-borne bacteria as a courier to deliver potent cancer-killing proteins into tumor cells. Colorectal cancers accounted for the second-most deaths caused by cancer in 2025, according to the National Cancer Institute, highlighting the importance of new strategies for therapy and treatment. The study is published in the journal Cell Chemical Biology.

Babies with congenital heart disease have altered brain networks that may serve as a helpful guide for improving treatment interventions or developing treatment strategies.

A UBC study finds raccoons solve puzzles even without food rewards, suggesting they are driven by curiosity and information-seeking

When the eye’s drainage system clogs, pressure builds up and causes damage. The pressure can lead to glaucoma and vision loss. New research, published March 9 in the journal Immunity, reveals that a specialized set of immune cells act as the cleanup crew, pointing to a promising new target for therapies to prevent a major cause of blindness.