The University of Delaware's Juan Perilla is part of an international team that discovered a previously unknown role for the viral protein integrase, which helps HIV insert itself into human DNA. Reported in Nature, the discovery provides a new frontier for drug development to combat the virus.

By probing the cellular and molecular processes that drive sleep, HHMI Investigator Amita Sehgal and her team are uncovering how snoozing helps ensure there’s a source of clean energy to power brain cells.

A novel method to manipulate the inner structure of cells connects several scientific fields and could represent a significant step in the treatment of neurodegenerative diseases, such as Alzheimer’s and Parkinson’s disease.

A new study from the School of Neurobiology, Biochemistry, and Biophysics reveals a surprising insight into the operation of the ancestral brain: the visual cortex of turtles is capable of detecting unexpected visual stimuli in a way that is independent of their position on the retina, a property that, until now, was thought to exist only in the highly developed cortices of mammals, including humans. In light of these findings, the research team assesses that advanced brain mechanisms previously thought to be unique to mammals were already present hundreds of millions of years ago.

Understanding how microscopic interactions between proteins in cells produce large-scale organization and asymmetry is a fundamental question in cell biology. In a recent study, researchers from Japan investigated how actin and myosin create cell-scale structures using experimental setup. They found that Chara corallina myosin XI—a fast motor protein—drives actin filaments into large unidirectionally rotating rings. Their findings reveal physical principles of self-organization, inspiring new ways to design self-organizing biomimetic materials for biotechnological applications.

Postpartum breast cancer is diagnosed five to ten years after giving birth. It is associated with a higher risk of metastasis and a lower survival rate compared with women who have not been pregnant or those diagnosed during pregnancy. A team from the Institut Pasteur set out to understand the mammary gland mechanisms involved in tumor formation during involution, a major tissue remodeling process that occurs after pregnancy. In a preclinical study the scientists reveal how senescence, a cellular response inducing stable cell cycle arrest, plays an ambivalent role during mammary gland involution. While it is crucial for the normal tissue remodeling process in the mammary gland, senescence can also be hijacked by tumor cells to help them spread. This discovery, published in Nature Aging on February 18, 2026, suggests that targeting senescent cells during mammary gland involution could reduce the risk of postpartum breast cancer.