CLPTM1L remodels lipid rafts to promote glioblastoma growth
Peer-Reviewed Publication
Updates every hour. Last Updated: 13-Jun-2026 22:15 ET (14-Jun-2026 02:15 GMT/UTC)
The plasma membrane is more than a passive boundary. It is organized into dynamic lipid-rich microdomains, often referred to as lipid rafts, that concentrate receptors and signaling molecules. In glioblastoma (GBM), the most aggressive primary brain tumor in adults, the epidermal growth factor receptor (EGFR) signaling is a major oncogenic driver. Yet how tumor cells maintain the membrane platforms that support such proliferative signaling has remained incompletely understood.
Kyoto, Japan -- Bright colors in animals are beautiful but often considered risky because they are more obvious to predators. However, conspicuous colors can also serve defensively, signaling toxicity or even luring predators away from more vulnerable body parts.
Previous studies have shown that the presence of predators such as dragonfly nymphs can induce tadpoles to develop bright orange tail coloration, an ability called phenotypic plasticity. But how this color change helps them avoid predation has not been clear. While observing tadpoles of the East Japan tree frog, Dryophytes leopardus, a team of researchers at Kyoto University was inspired to investigate how their predator-induced orange tails function as a defensive trait.
"After seeing these tadpoles with orange tails at the university's experimental farm, I wondered what role such a bright tail could have," says corresponding author Akihiro Noda.
A new University of Florida co-authored study in Science found that African elephants are a keystone species whose loss can trigger ecosystem collapse, including major declines in dung beetles and the ecological services they provide.
W. M. Keck Foundation Bridge Funding Initiative grants $600,000 to Salk scientist, graduate student pairings. The three teams will each tackle their own projects, spanning cancer, neuroscience, and genetics. The grants accelerate high-risk, high-reward science that otherwise would be difficult to pursue in today’s science funding landscape.