Researchers at DZNE and Charité – Universitätsmedizin Berlin have identified fundamental mechanisms underlying a severe neurological condition known as “IgLON5 encephalitis”, in which the immune system mistakenly attacks brain cells. Their findings have been published in the journal Science Advances.

Immune effector cell-associated hemophagocytic lymphohistiocytosis-like syndrome (IEC-HS) is a rare but life-threatening complication of CAR-T therapy. This review summarizes key diagnostic features, risk factors, and current management strategies, emphasizing early recognition and targeted intervention to improve clinical outcomes.

The Na⁺-NQR enzyme is vital for energy production in pathogenic bacteria like the one that causes cholera, making it a highly promising target for new antibiotics. Researchers combined modified artificial intelligence techniques with extensive supercomputer simulations to visualize the hidden, dynamic movements of this enzyme during sodium transport. The study revealed that sodium binding and electron transfer act as a precise dual trigger, driving specific subunits of the enzyme through a cycle of shape changes to pump sodium ions across the cell membrane. Unlocking this pumping mechanism provides a powerful new computational framework for understanding cellular energy-converting molecular machines and could accelerate the design of targeted antibacterial drugs.