Metabolic dysfunction-associated steatotic liver disease (MASLD), a spectrum of liver conditions ranging from simple steatosis to steatohepatitis (MASH), fibrosis, and cirrhosis, represents a global health epidemic with no approved pharmacotherapies.

 

The liver plays a central role in maintaining systemic energy homeostasis during fasting by mobilizing lipid reserves, a process often accompanied by transient hepatic steatosis. Dimethylarginine dimethylaminohydrolase 1 (DDAH1), a key enzyme metabolizing asymmetric dimethylarginine (ADMA), has been shown to protect against NAFLD under nutrient-overload conditions. However, its role in the physiological context of fasting remained elusive.

Why do some children develop a brain that is too small (microcephaly)? An international research team involving the German Primate Center – Leibniz Institute for Primate Research (DPZ), Hannover Medical School (MHH), and the Max Planck Institute of Molecular Cell Biology and Genetics has used human brain organoids to investigate how changes in important structural proteins in the cell lead to this severe developmental disorder (EMBO Reports).

Today, the Arabian Gulf is home to manatee-like marine mammals called dugongs that shape the seafloor as they graze on seagrasses. A newly described fossil site in Qatar reveals that ancient sea cows engineered aquatic ecosystems in a similar way more than 20 million years ago.

By testing for microbes in termite excrement, researchers can distinguish old droppings from fresh, and whether a colony is actively chewing its way through a home.

A research team at the Center for Neuroscience Imaging Research (CNIR) within the Institute for Basic Science (IBS), together with Sungkyunkwan University (SKKU), has developed a new class of ultra-thin, flexible bioelectronic material that can seamlessly interface with living tissues. The researchers introduced a novel device called THIN (Transformable and Imperceptible Hydrogel-Elastomer Ionic-Electronic Nanomembrane). THIN is a membrane just 350 nanometers thick that transforms from a dry, rigid film into an ultra-soft, tissue-like interface upon hydration.