Volume 42 of SLAS Discovery includes one review, eight original research articles and 1 short communication for oncology, infectious disease, immunology and computational biology research through innovative screening platforms for accelerating the discovery of targeted therapies, diagnostic biomarkers, and mechanistic insights across diverse disease areas.

UC San Diego researchers have received a $12.6 million award from the National Institute on Drug Abuse to establish the Polysubstance Addiction Research Center, a multidisciplinary center designed to uncover the biological factors that contribute to addiction across multiple substances.

Dentin formation, a crucial process during tooth development, results from the secretion of organic matrix from specialized cells called odontoblasts. However, the roles of the mechanosensitive channels Piezo1 and Piezo2 in odontoblast differentiation are unclear. Now, researchers from the University of Maryland addressed this knowledge gap using Piezo1/Piezo2 conditional knockout mice. Piezo1/Piezo2 double knockout impaired odontoblast differentiation and Wnt signaling. This study indicated that Piezo1 and Piezo2 contribute to odontoblast terminal differentiation, at least in part, by modulating Wnt signaling.

From North America to Patagonia: Researchers at the University of Würzburg have reconstructed how New World blackbirds spread across the Americas over millions of years.

An international team of researchers led by Dr. Meng Li at Shenzhen University has conducted a comprehensive survey of fungal communities across seven representative Chinese mangrove wetlands. Using high-throughput sequencing of 300 sediment samples, the team discovered that over one-third of fungal diversity remains unclassified at the phylum level, making mangrove sediments a major reservoir of uncharacterized fungal life. The study reveals that fungal community assembly is governed by a hierarchical framework operating across three scales: macro-climatic filtering by temperature and dispersal limitation, local edaphic filtering by salinity and nutrient stoichiometry, and micro-scale biotic interactions through cross-kingdom co-occurrence networks. These findings, published in Mycology, provide a theoretical foundation for understanding microbial community stability in coastal ecosystems under global change.

Schooling fish have long fascinated us with their mesmerizing collective movements and seemingly perfect coordination. But a new study on clonal mollies suggests that this behavior is not innate. During their first days of life, the fish still display distinct individual behaviors, and it is only around one month of age that they begin to form cohesive shoals, developing the coordinated movements characteristic of the group. However, several shoals of genetically identical clones begin to behave differently after a few weeks. The study was conducted by the Cluster of Excellence ‘Science of Intelligence (SCIoI)’, the Leibniz Institute of Freshwater Ecology and Inland Fisheries (IGB), Humboldt Universität zu Berlin, and UC Davis and published in Current Biology.