African frogs haven’t forgotten the ice ages. Scientists can tell by where they live.
Peer-Reviewed Publication
Updates every hour. Last Updated: 26-May-2026 18:15 ET (26-May-2026 22:15 GMT/UTC)
A team of university and Tribal researchers has developed a blueprint for creating research agreements that enable respectful research with Tribes and on Tribal lands. The guidance was developed to address shortcomings in most research policies that are written without Tribal input, often leaving Tribes with unclear protections, data vulnerabilities, and limited control over how information about their lands and people is used.
The outcomes of critically ill patients with liver cirrhosis are particularly poor when ARDS develops. Despite this scenario, the robust studies on the prevalence, prognosis, and prognostic factors of ARDS in patients with cirrhosis have remained scarce. To address this, researchers from France carried out a bicentric retrospective study with the largest cohort of patients with cirrhosis and ARDS. The study is the first to identify independent prognostic factors for short-term mortality in this population.
Studies explored the role of H3K27me3 in early embryonic cell fate decisions via PCGF1-knockout models, finding that PCGF1 deficiency leads to embryonic lethality and blocked gastrulation. Mechanistically, PCGF1 maintains H3K27me3 homeostasis to silence pluripotency genes and balance epigenetic marks, highlighting dynamic H3K27me3 remodeling as a key driver of early lineage specification with implications for developmental biology and regenerative medicine.
Prenatal oxycodone exposure changes how the placenta sends signals to the fetus. A new study revealed how alterations in the protein composition of placental small extracellular vesicles (sEVs) impact fetal heart development. These changes suggest that maternal opioid use may raise the baby’s risk for future heart problems.
Preconditioning mesenchymal stem cells with TNF-α enriches their small extracellular vesicles with anti-inflammatory microRNAs, especially miR-146a-5p, enabling stronger suppression of macrophage-driven inflammation and better preservation of retinal structure and function in a mouse model of inflammatory retinal degeneration.