Primary central nervous system lymphoma (PCNSL) is a rare and highly aggressive lymphoma or tumor of the brain. While ventricular brain lymphoma is even rarer, its clinical characteristics and treatment strategies remain less explored. Now, researchers have evaluated the clinical features of PCNSL lesions involving the ventricles. They found that this rare tumor type shares key features with other brain lymphomas, suggesting a unified treatment approach.

Traumatic brain injury (TBI) is one of the most serious public health problems worldwide, leaving millions with lasting cognitive and physical disabilities. Despite decades of research, early diagnosis and effective treatment remain challenging. Now, researchers have explored a new frontier, theranostic nanomaterials, tiny engineered particles that can both diagnose and treat TBI, while addressing the limitations of traditional biosensing and therapy strategies.

Recently, the research team led by Professor Ling Shuai from the State Key Laboratory of Medicinal Chemical Biology at Nankai University has successfully activated the totipotency in mouse embryonic stem cells by overexpressing the key gene Hmgn3. Through mechanistic studies, the team discovered that Hmgn3 exerts its function by interacting with the Dux family genes. This study provides a brand-new strategy and model for research in early embryonic development and regenerative medicine.