Salk scientists have created a platform to study mitochondrial DNA mutations that lead or contribute to human disease, and generated a library of 155 mitochondrial DNA mutant cells using the platform. The platform, library, and findings will accelerate therapeutic development for mitochondrial disorders, as well as help scientists treat mitochondrial dysfunction in other diseases and conditions like cancer or aging.

A research team led by Dr. Xuewei Chen from Sichuan Agricultural University has developed a genetic strategy to enhance broad-spectrum disease resistance in rice without compromising plant growth and yield, a major challenge in crop breeding. The findings are published in The Crop Journal.

Scientists at the AI and Digital Science Institute of the HSE Faculty of Computer Science have developed a model capable of predicting protein–protein interactions with 95% accuracy. GSMFormer-PPI integrates three types of protein data (including information about protein surface properties) to analyse relationships between proteins, rather than simply combining datasets as in previous models. The solution could accelerate the discovery of disease molecular mechanisms, biomarkers, and potential therapeutic targets. The paper has been published in Scientific Reports.

A new study develops and validates a nomogram to predict the need for continuous renal replacement therapy (CRRT) in patients with acute kidney injury (AKI) after lung transplantation. By integrating perioperative and early postoperative variables, this tool supports timely, individualized intervention, helping clinicians potentially reduce CRRT needs and improve patient outcomes in the complex post-lung transplant setting.