This study determined cryo-EM structures of midnolin-proteasome complexes, providing mechanistic insights to midnolin-catalyzed substrate degradation. Based on structural and mechanistic understanding, authors have engineered the midnolin system for targeted degradation of desired substrates, and provide the first proof-of-principle for degrading a non-native therapeutically high-profile target that is otherwise undruggable.

Lipids are not just energy sources and structural components of cell membranes – they also act as molecules that transmit signals within and between cells. A new Koselleck Project at the Institute of Pharmaceutical Chemistry at Goethe University Frankfurt and the Max Planck Institute for Heart and Lung Research focuses on certain products derived from arachidonic acid. These products exhibit beneficial effects in cardiovascular diseases as well as in Alzheimer’s dementia and chronic pain.

Researchers from the University of Cologne discovered how a specific dietary amino acid increases cellular energy, opening new possibilities for treating metabolic diseases / publication in Nature Cell Biology