• KAIST and Yonsei University uncovered how the MSC regulates LARS1-mediated activation of mTORC1 in response to amino acids

• Discovery pinpoints a key phosphorylation switch that initiates growth signaling

• Findings provide a foundation for developing a next-generation anticancer strategy that block abnormal growth signaling upstream of mTORC1

Work led by chemists at the University of Wisconsin–Madison is showing that there is a different way to think about designing reactions. Their fundamentally novel strategy, published recently in Nature, fixes a long-standing limitation in electron-transfer selectivity, could open up many otherwise inaccessible and potentially valuable coupling reactions. 

Harvard engineers used standard industrial weft knitting to create dense fabrics that snap between multiple stable 3D shapes, turning ordinary textiles into mechanical metamaterials. 

The low endosomal escape efficiency of endocytosis-based delivery has become a key barrier restricting therapeutic biomacromolecule applications in biomedicine. A review published in Biomedical Analysis highlights emerging non-endocytic transmembrane delivery strategies that bypass conventional cellular uptake pathways and enable direct cytosolic delivery of proteins, nucleic acids, and gene-editing tools. Led by Dr. Yang Liu from Hefei Comprehensive National Science Center, the review summarizes recent advances in physical, biomimetic, and bioengineered delivery platforms and discusses their potential for gene therapy, drug delivery, and cellular engineering.