Scientists at St. Jude Children’s Research Hospital leveraged fundamental features of chemical building blocks to transform chemical reaction analysis from minutes to milliseconds.

Recently, scientists at Insilico Medicine utilized the comprehensive generative chemistry engine Chemistry42 to discover a novel gut-restricted PHD inhibitor that shows promise for repairing the intestinal mucosal barrier and regulating immune responses in IBD. The study, published in Nature Biotechnology, highlights the role of Chemistry42 and its submodules in supporting drug candidate design and optimization. The research underscores the potential of advanced AI technologies to accelerate the fulfillment of urgent clinical needs.

Researchers have pioneered a new technique at the Swiss Light Source SLS called X-ray linear dichroic orientation tomography, which probes the orientation of a material’s building blocks at the nanoscale in three-dimensions. First applied to study a polycrystalline catalyst, the technique allows the visualisation of crystal grains, grain boundaries and defects - key factors determining catalyst performance. Beyond catalysis, the technique allows previously inaccessible insights into the structure of diverse functional materials, including those used in information technology, energy storage and biomedical applications. The researchers present their method in Nature.