Novel cancer therapy combining multi-hydroxylated fullerene (MF) nanoparticles and mTOR inhibitors triggers organelle cascade collapse in tumors, disrupting cancer cells' self-repair capacity. By synchronizing the membrane-breaking effect of MF with dual autophagy regulation, this strategy induces lysosomal rupture, mitochondrial dysfunction, and endoplasmic reticulum stress while paralyzing cellular cleanup systems. Animal studies demonstrate potent tumor suppression and high safety, leveraging cancer cells' fragile organelle networks against them. The breakthrough establishes organelle communication disruption as a new anticancer paradigm, pioneering material science-enabled therapies independent of genetic targets.

The Frontiers Planet Prize, the world’s largest science competition to enhance planetary health by fast-tracking innovative research, has announced National Champions from 19 different countries who now advance to the International competition, which will award three winners $1M each to scale up their research. Suzanne Tank and co-authors from the Arctic Great Rivers Observatory (ArcticGRO), a multinational project founded at the Marine Biological Laboratory (MBL), were recognized for their publication, “Recent trends in the chemistry of major northern rivers signal widespread Arctic change,” published in Nature Geosciences.