Simulations reveal protein "dynamin" constricts cell membranes by loosening its grip
Peer-Reviewed Publication
Updates every hour. Last Updated: 10-Dec-2025 12:11 ET (10-Dec-2025 17:11 GMT/UTC)
Computer simulations revealed the detailed mechanism of how the protein "dynamin" works to form small vesicles within cells.
While dynamin uses GTP hydrolysis energy to change shape, it was unclear how this leads to membrane constriction. Simulations showed that instead of simply tightening, dynamin "loosens" (expands) at a certain stage to generate the force needed to narrow the surrounding membrane tube.
This study provides a clearer explanation for membrane deformation and vesicle formation processes in cells, offering insights for artificial nano-device design.
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