Integrated bioinformatic modeling of goniothalamin as a dual-target medicinal chemistry candidate against antibiotic-resistant Staphylococcus aureus and Escherichia coli
Peer-Reviewed Publication
Updates every hour. Last Updated: 26-Oct-2026 22:16 ET (27-Oct-2026 02:16 GMT/UTC)
A new computational study has found that goniothalamin — a natural plant compound — binds tightly to two critical bacterial proteins in drug-resistant Staphylococcus aureus and Escherichia coli, suggesting it could form the basis of a new class of antibacterial agents that work differently from conventional antibiotics and may be less likely to drive resistance.
The study, "Integrated Bioinformatic Modeling of Goniothalamin as a Dual-target Medicinal Chemistry Candidate against Antibiotic-resistant Staphylococcus aureus and Escherichia coli," was co-authored by Nawan Nawan, Septi Handayani, and Agnes Immanuela Toemon, and published in The Open Medicinal Chemistry Journal.Halogenated organic compounds (HOCs) are widely used in industrial and consumer products, but some are highly persistent and difficult to analyze and manage. In a new study, researchers have developed an innovative approach for carbon isotope ratio analysis of these compounds, which has been previously difficult. This approach will help track the source and environmental pathways of such pollutants, contributing to the development of effective management strategies.
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