Chinese chemists boost lignin’s sun protection factor from 5 to 66 and cut colour darkness by one-third through controlled radical grafting and TiO₂ nano-loading, offering a biodegradable alternative to petrochemical filters.

Reporting in the Journal of Bioresources and Bioproducts, researchers show that atom-transfer radical polymerisation couples waste-pulp lignin with the commercial UV absorber MBBT, producing sub-micron spheres that remain stable after three hours of intense ultraviolet irradiation.

This study uncovers a new molecular mechanism by which the E3 ubiquitin ligase PIAS4 orchestrates pluripotency exit and lineage commitment in porcine embryonic stem cells (pESCs). Using a genome-wide CRISPR screening approach, the researchers identified PIAS4 as a critical regulator that modulates histone H3K4me3 marks via SUMOylation-mediated stabilization of KDM5B. Loss of PIAS4 impaired stem cell differentiation, disrupted lineage specific gene programs, and altered mesendoderm specification through LEFTY2–SMAD signaling. These findings not only provide fundamental insight into porcine stem cell biology but also pave the way for applications in livestock breeding, artificial meat production, and regenerative medicine.

The senescence of bone marrow-derived mesenchymal stem cells is involved in osteoporosis. The combination of dasatinib and quercetin has been explored to alleviate bone loss by efficiently reducing senescent cell populations. However, senolytic therapy by dasatinib and quercetin requires a precise ratio for better therapeutic effects, which is hard to achieve by oral administration. Meanwhile, the poor water solubility of these compounds limits their bioavailability, and their non-specific action could hamper effective penetration and targeting within relevant tissues. Herein, we developed alendronate-functionalized liposomes carrying dasatinib and quercetin (Aln-Lipo-DQ), focusing mainly on senescence-associated osteoporosis induced by chemotherapy or radiotherapy. Alendronate helps liposomes deliver dasatinib and quercetin to the femur and tibias, effectively removing senescent cells from bone tissue and increasing bone volume fraction from 5.05% to 11.95% in the chemotherapy-induced osteoporosis mouse model. We also found a 2.91-fold increase in bone volume fraction in Aln-Lipo-DQ treated groups compared to the control in radiotherapy models. This selectively targeting bone and reducing senescent cells holds great promise for cancer treatment-related and senescence-associated bone disorders.

Researchers at the Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, report in ACS Nano the successful creation of artificial synaptic vesicles that can be remotely controlled by near-infrared (NIR) light. By embedding a phthalocyanine dye into lipid bilayers, the team achieved local heating that modulates membrane permeability, enabling precise release of neurotransmitters such as acetylcholine. These findings demonstrate that nanoscale heating can control communication between nerve cells. The work opens new avenues for non-genetic modulation of neuronal activity, with potential applications in neuroscience, drug delivery, and bioengineering.

A new study published in Translational Exercise Biomedicine (ISSN: 2942-6812), an official partner journal of International Federation of Sports Medicine (FIMS), reveals that a progressive, multi-component exercise program, enhanced by wearable sensor technology, can significantly counteract the debilitating effects of frailty in older adults. The 12-week intervention led to remarkable improvements not only in physical strength and balance, but also in cognitive abilities and overall quality of life, presenting an effective and practical strategy for community health management in an aging global population.

As part of an effort to better evaluate how pre-weaned calf and stocker calf treatments influence feedlot performance, Daniel Rivera, associate professor of animal science with the University of Arkansas System Division of Agriculture and Paul Beck, a professor and extension specialist for beef nutrition with Oklahoma State University’s department of animal and food sciences, published a summary of research on the topic in a special issue of Applied Animal Sciences, the American Registry of Professional Animal Scientists' official journal.