A new report presents suggestions to dramatically reduce firearm violence by 2040 through practical solutions grounded in evidence and accountability, recognizing constitutional protections while ensuring public safety.

Hypertension impairs blood vessels, neurons and white matter in the brain well before the condition causes a measurable rise in blood pressure, according to a new preclinical study from Weill Cornell Medicine investigators. The changes help explain why hypertension is a major risk factor for developing cognitive disorders, such as vascular cognitive impairment and Alzheimer’s disease.

About The Study: In concordance with Centers for Disease Control and Prevention (CDC) recommendations, the data from this study show a rapid rise in early measles vaccination in early 2025. These data suggest an increase in early vaccination started in February, even before the updated guidelines were issued, potentially due to clinician and/or parental concern.

New research has been published ahead-of-print by The Journal of Nuclear Medicine (JNM). JNM is published by the Society of Nuclear Medicine and Molecular Imaging, an international scientific and medical organization dedicated to advancing nuclear medicine, molecular imaging, and theranostics—precision medicine that allows diagnosis and treatment to be tailored to individual patients in order to achieve the best possible outcomes.

Highly pathogenic avian influenza viruses—those responsible for bird flu outbreaks—continue to pose challenges for human and animal health. New research led by microbiologist Louise Moncla of the Unviersity of Pennsylvania tracked H5N1 viruses in North America to better understand the role wild birds play in the current bird flu outbreak. These findings could lead to a shift in risk management and outbreak control measures.

Metabolic dysfunction-associated fatty liver disease (MAFLD) poses a significant challenge in modern medicine due to its high prevalence. The pathogenesis of MAFLD involves a complex dysmetabolic process consistent with the “multiple-hit” hypothesis. This process includes excessive triglyceride (TC) accumulation within hepatocytes, lipotoxicity, insulin resistance (IR), chronic low-grade inflammation, and increased oxidative stress. The role of leptin in the liver has been extensively studied, demonstrating both direct effects on hepatic cells and indirect actions mediated through the central nervous system (CNS). In MAFLD, leptin modulates several physiological processes: it improves glucose metabolism by enhancing insulin sensitivity and lowering glucose levels; regulates lipid metabolism by promoting β-oxidation and TC export while inhibiting lipogenesis; and contributes to fibrogenesis by upregulating transforming growth factor-β (TGF-β) expression and activating hepatic stellate cells (HSCs) and the immune response. This review explores the structure of leptin, its primary physiological functions, its potential role in MAFLD pathogenesis, and its promise as a novel therapeutic target.