High blood pressure is strongly tied to obesity. But the mechanism linking fat to blood vessel function has remained a mystery—especially the contribution of thermogenic brown and beige fat, a heat-producing form of adipose tissue that is linked to better cardiovascular health. The loss of thermogenic beige fat unleashes the enzyme QSOX1, which results in blood vessel fibrosis and increased vessel sensitivity to blood pressure-raising signals, driving hypertension. The findings reveal a new molecular pathway, offering scientists a target for vascular disease and paving the way for future precision therapies for hypertension.

A newly developed radiopharmaceutical pair can precisely detect and effectively treat--completely eradicating tumors in certain preclinical models--gastric and pancreatic tumors. Targeting the well-defined and accessible biomarker claudin-18.2, the theranostic technique has the potential to move the field substantially closer to durable disease control and potentially cure--in otherwise difficult-to-treat solid tumors. This research was published in the January issue of The Journal of Nuclear Medicine.

As Congress debates the future of telehealth coverage under Medicare, a study shows that it hasn’t led to an increase in total visits since 2020, but different medical specialties, especially mental health, have different rates of use.

University of Texas at Dallas researchers, in partnership with Texas-based biotech company EnLiSense, have demonstrated a pioneering wearable perspiration-based sensor that measures two key hormones that regulate the body’s sleep-wake cycle. The electrochemical sensor continuously monitors cortisol, which promotes wakefulness, and melatonin, which signals the body to sleep.