Esophageal adenocarcinoma (EAC) is the sixth most deadly cancer worldwide for which no effective targeted therapy exists. Patients need to rely on chemotherapy which is started ahead of surgical interventions in the hope to shrink or control tumors. However, most patients become resistant to certain NACTs, leading to poor outcomes.

 

To enable clinicians to rapidly test different chemotherapies and determine the best treatment courses, Wyss Institute researchers and their collaborators at McGill University have developed a precision oncology Organ Chip platform that accurately and actionably predicts chemotherapy responses of individual patients with EAC in a clinically useful timeframe.

An approach to treating childhood depression, developed by researchers at WashU Medicine, involves therapists coaching caregivers in helping to build a nurturing and supportive environment for the child. This specialized therapy leads to long-term remission and other benefits, according to a new study.

Mitochondria are highly dynamic organelles that adapt to cellular stress and metabolic demands through processes such as fission, fusion, mitophagy, and transport, all of which are vital for maintaining cellular signaling and metabolic homeostasis. Fission facilitates mitochondrial division and biogenesis, while fusion enhances mitochondrial fitness and metabolic flexibility by mitigating damage. Together, these processes play a critical role in regulating cellular stress responses and apoptosis. Dysregulation of mitochondrial dynamics has been linked to impaired development and cancer progression, including breast cancer metastasis. A comprehensive understanding of mitochondrial dynamics in breast cancer progression is essential for advancing precision medicine. This review delves into the intricate molecular mechanisms governing mitochondrial biogenesis, fission, fusion, and mitophagy, with a particular focus on the role of mitophagy in maintaining mitochondrial homeostasis and its connection to metastasis progression. Furthermore, it discusses potential therapeutic strategies targeting mitochondrial dynamics and highlights the critical steps necessary to translate these approaches into clinical trials.

A UCLA study shows that removing a modest $45 out-of-pocket fee significantly improved access to 3D mammography,  increasing overall usage several percentage points and particularly benefitting underserved patient populations,