In a comprehensive analysis of state and local sanctuary and anti-sanctuary policies, researchers have mapped the rapidly evolving legal immigration landscape in the US from 2000 to 2021. The dataset sheds light on trends in immigration legislation including ”punitive” preemption, state government tendencies to enact laws that are ideologically opposed to the current federal administration, and conservative states using preemption to control liberal localities. The findings of the study in the American Journal of Preventive Medicine, published by Elsevier, can be used to examine how changes in state and local immigration policies drive health outcomes among immigrants and their communities.

Aging often brings metabolic troubles, and a new study in Engineering may explain why. Scientists found a special sugar-modified antibody called fucosylated IgG builds up in aging fat tissue. It worsens inflammation and scarring while weakening fat’s normal function. This discovery points to a new way to ease age-related metabolic problems by adjusting this antibody’s sugar structure, giving fresh hope for healthy aging.

B lymphoma remains tough to treat with current cell therapies due to high costs and limited antigen targeting. A new study in Engineering compares two live-cell glycocalyx engineering methods to boost immune cells against B lymphoma. By equipping NK and CAR-T cells with CD22-targeting glycans, researchers enhance tumor recognition and killing. This transgene-free strategy offers a practical, cost-efficient path to better adoptive cell therapies.

Chinese herbal medicines have given birth to many classic drugs, but their complex ingredients and unclear mechanisms slow new drug development. A new study in Engineering proposes phenotype–target coupled drug screening, combining phenotype-based and target-based discovery with AI, multiomics, and organ-on-chip models. This efficient framework helps locate active compounds, clarify targets, and boost success rates for herbal drug research and development.