By establishing an iron overload-induced hepatic ferroptosis model, scientists from Japan have identified iFerroptosis–an integrated gene signature for ferroptosis. They evaluated the associated genes in both mice and human liver injury systems, validating the potential use of iFerroptosis as a biomarker for hepatic ferroptosis. By highlighting the role of ferroptosis in liver injuries, this study offers insights into unique therapeutic targets for ferroptosis.

Epilepsy is among the most common neurological conditions, marked by unpredictable seizures, accidents and injuries, reduced quality of life, stigma and—in the worst case—premature death. But a program—developed over several years by a Case Western Reserve University-led research team—that teaches people with epilepsy how to “self-manage” their disorder is showing positive results. The program has been found to help people with epilepsy reduce related health complications and improve their mood and quality of life, according to a new study recently published in the peer-reviewed journal, Epilepsy & Behavior.

CRISPR-based gene editing holds great promise, but off-target effects remain a major concern, especially across diverse genetic backgrounds. A new study presents a web-based tool that enhances off-target site prediction by incorporating individual genetic variants. Developed using the human genome and pepper plant cultivars, the tool improves accuracy at the haplotype level. This user-friendly, login-free platform offers researchers a powerful way to personalize and safeguard genome editing applications across fields.

Improved treatment regimens have increased the life expectancy of individuals infected with HIV. However, these individuals are at a higher risk of developing other comorbidities—one such condition that has been debated upon is osteoarthritis (OA). Now, researchers from Shanghai Jiaotong University have uncovered a link between protease inhibitors—drugs utilized in HIV management—and the acceleration of OA development.