Sepsis and septic shock are the leading causes of death in intensive care units worldwide.  Controlling the dysregulated host response that drives inflammation, hemodynamic collapse, and multiple organ failure is challenging. In a comprehensive narrative review, Italian and French researchers examine the clinical applications of the oXiris® membrane, an advanced extracorporeal blood purification filter designed to combine continuous renal replacement therapy (CRRT) with targeted removal of inflammatory mediators and bacterial endotoxins in critically ill patients.

Keck Medicine of USC researchers discovered that people with metabolic dysfunction–associated steatotic liver disease (MASLD), the most common liver condition in the country affecting one-in-three adults, face significantly higher risk of liver fibrosis, or harmful scarring of the liver, if they engage in heavy episodic drinking. 

BUFFALO, NY — April 2, 2026 — A new research paper was published in Volume 18 of Aging-US on March 24, 2026, titled “Age-specific relationship between the modulation of brain dynamics in response to task demands and bimanual performance.”

As survival rates for female-specific cancers continue to rise, therapy-related myeloid neoplasms (t-MN) have become a critical long-term complication threatening survivors’ health. This systematic review by the team from Union Hospital summarizes the multi-factorial pathogenesis of t-MN, analyzes current treatment dilemmas, and puts forward female-focused management strategies. It provides a comprehensive theoretical framework for clinical precision prevention, early monitoring and targeted intervention of t-MN.

Glioma remains one of the deadliest brain cancers, characterized by aggressive growth and limited treatment options. In a new study, researchers from Ningxia Medical University uncovered that choline kinase alpha (CHKA) directly interacts with the epidermal growth factor receptor (EGFR) to activate the MAPK signaling pathway, thereby promoting glioma cell proliferation, migration, and invasion. This discovery sheds light on a previously unrecognized oncogenic axis, the CHKA/EGFR/MAPK pathway, offering fresh opportunities for targeted glioma therapy.

In this study, we revealed the pulmonary pathogen profiles of immunosuppressed ICU patients based on CD4⁺T-cell counts: the severe group showed a predominance of fungal/rare infections, whereas in the moderate group, bacterial infections were prevalent, often involving oral commensals. These findings underscore the potential of immune-status stratification to guide more precise empirical antimicrobial therapy. Future large-scale, multicenter studies are warranted to validate these associations and their impact on clinical outcomes.

Researchers from the Biomedical Data Science Laboratory (BDSLab) at the ITACA Institute of the Universitat Politècnica de València have developed a new method based on magnetic resonance imaging that enables objective quantification of the growth of the most aggressive brain tumours, particularly glioblastoma.

The study, published in the scientific journal Medical Physics, addresses one of the main clinical challenges in the diagnosis and treatment of this tumour: its high capacity to infiltrate healthy brain tissue.

In their work, the UPV's BDSLab team presents a new biomarker, the Dynamic Infiltration Rate (DIR), capable of identifying different patterns of tumour growth and independently predicting patient survival.

Some pathogens use temperature as a trigger and activate virulence only after entering the warmer environment of a host. A research team from Ruhr University Bochum, Germany, and the University of Münster, Germany, investigated how a diarrheal pathogen suppresses its virulence outside of the human body. Their study focused on the DNA-binding protein Fis, which is more abundant at cooler ambient temperatures of around 25°C. Under these conditions, Fis represses the expression of virulence genes. When Fis is absent, a cascade of virulence genes is induced, and bacteria that are normally harmless at this temperature become lethal to poikilothermic moth larvae. The findings were published online in PLoS Pathogens on March 25, 2026.

Researchers at Tohoku University have imagined a future where you can assess eye health at a local supermarket, train station, or in remote regions without hospital access using a portable, inexpensive eye scanner.