Precise intracellular transport is essential for neuronal function, yet the exact mechanism of selective cargo delivery by motor proteins remains unclear. Now, researchers from Japan have reported that distinct kinesin-2 motor protein assemblies have specific cargo preferences. Their report mentions that the KIF3B/B/KAP3 kinesin complex specifically transports TRIM46 to the axon initial segment of a neuron. This discovery reveals the underlying mechanism of transport specificity in neurons and may help understand transport defect-related disorders.

Environmental enrichment (EE), which involves a combination of voluntary exercise and social interaction has been known to improve poststroke functional recovery. However, its effect on chronic inflammation and white matter pathology remains elusive. Now, a new study reveals that EE improves sensorimotor recovery after stroke while weakening correlation of infarct size with chronic inflammation and myelin damage. It also identifies TREM2-positive microglia in white matter as a potential cellular signal associated with improved functional recovery.

Low aerobic fitness and muscle weakness increase the risk of complications and death in people with heart failure. This systematic review found that combined aerobic and resistance training improves aerobic fitness and muscle strength more than aerobic training alone. This advantage remained even when total exercise time was matched. Adding resistance training may therefore be an effective strategy to enhance aerobic fitness, build muscle strength, and potentially improve prognosis in patients with heart failure.

A new review reveals how focal adhesion kinase (FAK) acts as a central regulator of tumor progression and immune suppression in solid tumors. The study summarizes molecular mechanisms of FAK activation and highlights emerging combination therapies and next-generation inhibitors that could reshape future cancer treatment strategies.

Thanks to supercomputing, the research was able to analyze the activity of 20,000 genes in more than one million cells with unprecedented resolution, revealing different aging dynamics between men and women, which will be key to achieving precision medicine.

This study highlights that many characteristics of immune system aging that were previously considered universal actually present specific dynamics according to biological sex.

Could mining Reddit with AI help spot drug side effects earlier? A new Penn study suggests it might. Using large language models to map patient posts to standardized medical terms, researchers analyzed more than 400,000 Reddit posts about GLP-1s and found both known side effects and possibly underrecognized symptoms, like menstrual changes. The team says the approach could eventually help generate early safety signals for other drugs and wellness trends discussed online.

The Center for Myokine Convergence Research at Korea University College of Medicine (Director: Professor Hyeon Soo Kim, Department of Anatomy, Korea University College of Medicine) has signed a memorandum of understanding (MOU) with MFC to jointly develop therapeutics for muscle loss in astronauts.