Ovarian cancer (OC) is a major global health problem. The main treatments are surgery and chemoradiotherapy. A drawback of the latter is that repeated treatments are likely to lead to cancer cells developing resistance to the drug, resulting in recurrence, development of metastases, and poor prognosis for patients. Consequently, there is interest in combining chemoradiotherapy with treatment using active components extracted from natural products. One such component is resveratrol (RVT), which is a natural anti-tumor ingredient extracted from plants. Although there are many reviews on the biological activity of RVT, only a few studies have been performed to investigate the diversity of protein binding of RVT with OC and the application of various novel drug formulations containing RVT to treat OC. The review presented here may provide some ideas for the prevention and treatment of OC.

Paired Box 3 (PAX3) is a protein that plays a critical role in the formation of tissues and organs during embryonic development and can positively (and less frequently, negatively) regulate gene expression. While progress has been made to advance our understanding of this critical and multi-faceted protein, there is still much that is unknown about the mechanisms by which PAX3 controls such a wide array of key cellular functions.

 

In a new review in the journal Biomolecules, researchers report that PAX3 is essential for the development of nerves, muscles, and melanocytes in embryos, and also plays a role in maintaining adult tissues in stem cells. Additionally, in some cancers, such as some muscle tumors and melanoma, researchers found that PAX3 is present in abnormally high levels and  promote tumor progression.

The postpartum period is one of the most challenging times for mothers of all backgrounds. In addition to providing 24-hour care for a newborn infant (and likely other members of the family) on limited, sporadic sleep, these individuals are recovering from childbirth. From c-sections and other surgical procedures to mastitis and UTI infections, new mothers face a myriad of health issues and complications in the weeks and months after delivery.

Add the transportation, childcare, and access barriers faced by many rural, minority and low-resource communities, and the challenges are amplified even further. Telehealth has emerged as an increasingly widespread strategy for mitigating these obstacles, particularly during and after the COVID-19 pandemic when health care systems were strained/disrupted and in-person care posed additional safety concerns for vulnerable populations.

A Dartmouth team reports a new phone-based tool that measures tissue health using LED light and a topical cream that activates the natural molecules that indicate cellular oxygen levels. The tool could provide a simple and affordable at-home method for monitoring vascular diseases, infections, and other common conditons without expensive camera systems, sensors, or inpatient care. 

Young children who attend nursery get sick more often than those who don’t, but they will go on to have fewer illnesses during early school years, finds a new review of evidence by a group of parent-scientists involving University College London (UCL) researchers.

For decades, members of the Rural Health Research Center have been studying how childhood experiences impact long-term outcomes. Much of this research has examined the negative effects of adverse childhood experiences (ACEs) such as divorce, abuse and household dysfunction on factors like health, employment, mental health and relationships. Positive childhood experiences (PCE) also play an important role in lifelong health and well-being, and Center researchers have long looked at how the presence or absence of PCEs shape individuals as they grow into adults.

Young people around the world are increasingly suffering from anxiety disorders. A team from the Mental Health Research and Treatment Center (FBZ) at Ruhr University Bochum, Germany, has investigated how this development correlates to changes in societal expectations and values in education. The researchers were able to show that religious belief plays a key role in protecting the mental health of children and adolescents. Countries where religiosity has lost significance exhibit a relatively high increase in the incidence of anxiety disorders, as the researchers report in the journal Developmental Science from February 11, 2026.