Maternal disorders remain critical indicators of national development and public health. In this study, researchers analyzed the burden of maternal disorders in China from 1990 to 2023 using data from the Global Burden of Diseases, Injuries, and Risk Factors Study 2023. The findings reveal a substantial decline in prevalence, mortality, and disability-adjusted life years over the past three decades, alongside notable shifts in leading causes and emerging challenges associated with China's changing fertility policies.

Genetic alterations in TP53 and CDKN2A can shape the immune response during early oral cancer development. Researchers from Tokushima University reveal that imbalanced p53–RB signaling activated the cGAS–STING pathway, allowing increased inflammatory signaling and infiltration of cytotoxic T cells and natural killer cells. This immune response was associated with delayed progression to invasive oral cancer. The findings highlight how specific tumor-suppressor alterations can influence antitumor immunity and progression during early carcinogenesis.

Researchers at The University of Texas MD Anderson Cancer Center and collaborating institutions in Texas developed an artificial intelligence (AI) model that helps explain how immune cells find their way to specific locations in the body and why they avoid others. The findings could help scientists better understand cancer, autoimmune diseases and treatment response.

The tumor-confined nano-activator (iCLAN_TSP-SAg) can drive localized expression of bacterial superantigens within tumors, enabling potent, antigen-independent T-cell activation while avoiding systemic toxicity.