From urinary tract infection to brain abscess: How bacterial subpopulations can spread to distant body sites
Peer-Reviewed Publication
Updates every hour. Last Updated: 26-Oct-2026 00:16 ET (26-Oct-2026 04:16 GMT/UTC)
Researchers from the University of Cologne, the German Center for Infection Research (DZIF), and the Broad Institute of Harvard and MIT present a remarkable clinical case in the New England Journal of Medicine. The case provides new insights into the evolution of bacterial pathogens and presents the concept of heterovirulence, i.e., the simultaneous presence of subpopulations with different levels of virulence within a single infection.
Multidrug resistance is making life-saving antibiotics increasingly ineffective, leaving doctors with a few options to treat deadly bacterial infections. A new study has identified a bacterial peptide that reprograms multidrug-resistant Escherichia coli, making it vulnerable to last-resort polymyxin antibiotics. The researchers also developed an extracellular vesicle-based delivery platform that restored antibiotic activity at lower doses while reducing toxicity, introducing a new strategy that manipulates bacteria's own biology to fight drug resistance.
Researchers from HSE University–Perm used EEG to study how sugar cravings and interest in healthy eating affect the evaluation of Cola-flavoured beverages. During the tasting, participants assessed the taste of each beverage and named the maximum amount they would be willing to pay for it. The results showed that the more interested a person was in their health, the harder and more cognitively taxing it was for them to decide whether they were willing to pay, and the smaller the amount they were ultimately willing to spend. The study was published in the British Food Journal.
A new mouse study led by UCLA Health suggests that inflammation during pregnancy can trigger autism-like changes in offspring, but also that those brain and behavior effects may be rapidly but temporarily reversible in adulthood with a short-term dose of the immunosuppressive drug rapamycin. The study did not identify rapamycin as a viable treatment for these symptoms in humans given its temporary effects and potential for toxicity from repeated doses. Instead, researchers said the drug’s effects revealed new therapeutic targets for the development of future treatments.
An international study involving LMU found regional differences in childhood lymphoid leukemia mortality across Brazil.
Many countries are using too many powerful and inappropriate antibiotics, fuelling antibiotic resistance concerns, while millions lack access to the specific drugs they need. That is according to a major international study of antibiotic use published today in The Lancet Public Health.
Researchers at Osaka Metropolitan University discovered that vitiligo may involve more than the immune-mediated destruction of pigment-producing cells. Instead, they found that some melanocytes persist within vitiligo lesions but enter a reversible “dedifferentiated-like state” in which they stop producing pigment but are otherwise still intact. Pharmacological modulation of these pathways in experimental models restored melanocyte characteristics and pigment-related functions, suggesting that reactivating surviving melanocytes, in addition to controlling autoimmune responses, could represent a new therapeutic strategy for vitiligo.
Exercise finds improvements in pain and function may fall short of what patients would notice in daily life, but more studies are needed to make firm conclusions, a new Cochrane review finds.