The research team led by Xiaolin Ni and Erping Long introduced a novel concept positioning centenarians as a model of immune resilience in the context of multimorbidity.
Peer-Reviewed Publication
Updates every hour. Last Updated: 31-May-2026 09:15 ET (31-May-2026 13:15 GMT/UTC)
Multimorbidity is defined as the concurrent presence of two or more age-associated diseases within an individual, which often results in detrimental health outcomes. Immunosenescence, the gradual deterioration of the immune system associated with aging, constitutes a significant risk factor for the development of these conditions. Moreover, certain diseases may exacerbate immunosenescence, thereby establishing a self-perpetuating pathological cycle. This bidirectional interaction forms a complex pathological network that presents considerable challenges for both the investigation and prevention of multimorbidity. In light of these challenges, it is pertinent to consider whether a paradigm shift in research and intervention strategies—centered on protective factors or anti-aging mechanisms—could facilitate substantial advancements in this field. On October 13, 2025, a research team led by Associate Researcher Xiaolin Ni and Researcher Erping Long from the Institute of Basic Medical Sciences at the Chinese Academy of Medical Sciences published an article entitled "Centenarians: a model of immune resilience against multimorbidity" in the journal Life Medicine. By examining the mechanistic interplay between immunosenescence and multimorbidity and referencing the unique immune profiles of centenarians, the authors proposed a novel systemic therapeutic paradigm termed IMET. This approach focuses on the modulation and restoration of the immune microenvironment, thereby offering innovative research directions and intervention strategies aimed at mitigating the burden of aging-related multimorbidity.
A study by The University of Osaka reveals that people who have had COVID-19 are more likely to wear masks. This is driven not by fear, but by an increased awareness of being a potential "silent carrier." The finding suggests that public health messages based on patients' real experiences, highlighting the risk of asymptomatic spread, could be more effective in encouraging preventive behaviors in the general population for future pandemics.
When California neighborhoods increased their number of zero-emissions vehicles (ZEV) between 2019 and 2023, they also experienced a reduction in air pollution. For every 200 vehicles added, nitrogen dioxide (NO₂) levels dropped 1.1%. The results, obtained from a new analysis based on statewide satellite data, are among the first to confirm the environmental health benefits of ZEVs, which include fully electric and plug-in hybrid cars, in the real world. The study was funded in part by the National Institutes of Health and just published in The Lancet Planetary Health. For the analysis, the researchers divided California into 1,692 neighborhoods, using a geographic unit similar to zip codes. They obtained publicly available data from the state’s Department of Motor Vehicles on the number of ZEVs registered in each neighborhood. ZEVs include full-battery electric cars, plug-in hybrids and fuel-cell cars, but not heavier duty vehicles like delivery trucks and semi-trucks. Next, the research team obtained data from the Tropospheric Monitoring Instrument (TROPOMI), a high-resolution satellite sensor that provides daily, global measurements of NO₂ and other pollutants. They used this data to calculate annual average NO₂ levels in each California neighborhood from 2019 to 2023. Over the study period, a typical neighborhood gained 272 ZEVs, with most neighborhoods adding between 18 and 839. For every 200 new ZEVs registered, NO₂ levels dropped 1.1%, a measurable improvement in air quality. To confirm that these results were reliable, the researchers conducted several additional analyses. They accounted for pandemic-related changes as a contributor to NO₂ decline, such as excluding the year 2020 and controlling for changing gas prices and work-from-home patterns. The researchers also confirmed that neighborhoods that added more gas-powered cars saw the expected rise in pollution. Finally, they replicated their results using updated data from ground-level monitors from 2012 to 2023.
Researchers from Kumamoto University have developed a new peptide-based technology that enables insulin—normally injected—to be taken orally while still powerfully lowering blood sugar. Their breakthrough, demonstrated in diabetic mice, could pave the way for needle-free insulin treatments that are safer, simpler, and more comfortable for patients.
A comprehensive new review published in the Journal of Management synthesizes decades of research to understand the epidemic of workplace loneliness. By analyzing 233 empirical studies, researchers from Portland State University have identified how workplace conditions contribute to isolation and offer evidence-based paths to reconnection.
The research emphasizes that loneliness is distinct from social isolation. While isolation is about being alone, loneliness is the subjective feeling that one’s social relationships are deficient—meaning employees can feel deeply lonely even in a crowded office.
"Given the connection between workplace characteristics and loneliness, organizations should consider that loneliness is not a personal issue, and instead is a business issue," said Berrin Erdogan, professor of management at Portland State. "Businesses have an opportunity to design jobs and organizations in a way that will prioritize employee relational well being."