A new perspective in bone metabolism: Targeting the lysosome–iron–mitochondria axis for osteoclast regulation
Peer-Reviewed Publication
Updates every hour. Last Updated: 16-Jan-2026 13:11 ET (16-Jan-2026 18:11 GMT/UTC)
This review focuses on the vital interconnections among lysosomes, iron metabolism, and mitochondria in osteoclasts. Lysosomes not only serve as the primary site for bone matrix degradation but also regulate intracellular iron mobilization. Mitochondria rely on iron to maintain energy metabolism, meeting the high metabolic demands of osteoclasts. Iron thus functions as a central mediator linking these two organelles.
The Gerontological Society of America (GSA) invites journalists to attend its 2025 Annual Scientific Meeting — the country’s largest interdisciplinary conference in the field of aging — from November 12 to 15 in Boston, Massachusetts. Qualified media representatives intending to cover the meeting may register free of charge.
Experiencing intense anxiety, lethargy, irritability, or sadness can be debilitating when trying to accomplish a simple task. For the task as monumental as caring for a baby, these symptoms of perinatal mood and anxiety disorders (PMADs) affect one in five mothers, many who feel unsupported.
In a new study, researchers surveyed hundreds of caregivers across the US about their mental health; networks of support; and experiences with caregiving, the healthcare system, and the workplace. They found that caregivers broadly experienced a lack of support in terms of PMAD screenings and mental healthcare, access to specialists, a lack of familial support, and inadequate paid leave.
Key findings include:
Improved allergy symptoms in infants who consumed blueberry powder (symptoms were pre-existing and not caused by blueberries). Reduced inflammation and signs of a stronger immune response. Positive shifts in gut microbiota, with changes considered beneficial for immune health.