Metabolic dysfunction-associated steatohepatitis (MASLD) is a liver disease with complex pathogenesis, characterized by abnormal lipid accumulation within hepatocytes, inflammation, and fibrosis. Its increasing incidence in recent years constitutes a serious public health concern, underscoring the need for identifying therapeutics that can improve hepatic lipid metabolism, alleviate liver burden, and reverse or mitigate disease progression.

Molecular Sustainable Solutions, a spin-off from the Universitat Jaume I of Castelló (UJI), secures €186,000 investment from BeAble Capital, a leading Science Equity fund specializing in disruptive scientific technologies. The disinfection and sterilization methods developed by Molecular Sustainable Solutions —more powerful and sustainable than current ones— are capable of tackling particularly resistant and dangerous microorganisms, such as the fungus Candida auris, popularly known as “the killer fungus.”

With this investment, Molecular Sustainable Solutions will be able to accelerate the maturation of its technology and move towards rapid market entry, strengthening its position as a benchmark in innovative solutions for public health and sustainability. The company, based at Espaitec, the UJI Science and Technology Park, thus becomes the first spin-off from the public university in Castelló to receive funding from a venture capital firm.

Polycyclic aromatic hydrocarbons (PAHs) are carcinogenic compounds introduced in food due to cooking methods such as smoking, grilling, and frying. Recently, researchers from Seoul National University of Science and Technology have leveraged a new method called QuEChERS-GC-MS to extract and detect PAHs in common food items, finding the highest levels in soybean oil, followed by duck meat and canola oil.

Higher activity of PGC-1α enables brown fat cells in females to thermogenic activity and energy expenditure compared to males, reveals a study conducted in Japan. This research demonstrates that PGC-1α protein promotes phospholipid synthesis, which strengthens mitochondria of brown fat cells and enhances their heat-generating capacity in female mice. The findings reveal a female-specific mechanism of energy metabolism, boosted by PGC-1α and estrogen, which could inspire new therapies for the prevention of obesity and diabetes.

Recurrent meningiomas pose a major clinical challenge, often returning with increased aggressiveness and treatment resistance. Researchers from Korea University used single-cell transcriptomics to map tumor evolution from primary to recurrent states, uncovering COL6A3 as a key molecular driver that links tumor proliferation with immune modulation. The study advances our understanding of meningioma biology and also highlights COL6A3 as a promising prognostic biomarker and therapeutic target, paving the way for smarter risk stratification and precision therapies.