Monoclonal antibodies can block a key immune‑related protein that drives the spread of brain cell damage in Parkinson’s disease (PD). This protein, called glycoprotein nonmetastatic melanoma B (GPNMB), might be part of a promising strategy for developing a treatment that slows disease progression at its earliest stages, according to a new study published today in Neuron, from researchers at the Perelman School of Medicine at the University of Pennsylvania. 

Mayo Clinic announced that President and CEO Gianrico Farrugia, M.D., has decided to complete his tenure at the end of this year.

Building on previous findings, researchers are exploring how desynchronized circadian rhythms may trigger brain inflammation associated with dementia risk.

Teens in disadvantaged neighborhoods are more likely to smoke, but it depends on whether they live in rural or urban areas.

Frequent exposure to real-world firearm violence through media is associated with worse mental health outcomes, according to Rutgers researchers.

Their study, published in BMC Public Health, found that frequent exposure to firearm-related content is linked to higher levels of depression and more days of poor mental health among adults in the United States.

Researchers have developed artificial intelligence (AI) models that can scrutinize electronic health records (EHR) and electrocardiograms to identify individuals in the general population at elevated risk for sudden cardiac arrest — a condition that causes more than 400,000 U.S. deaths annually and has a survival rate of only 10%. 

The finding represents a significant advance in predicting a largely unpredictable medical emergency that often strikes people with no known heart disease.  

"Using artificial intelligence applications and health records data, the prediction of cardiac arrest in the general population is feasible,” said Dr. Neal Chatterjee, the study’s lead investigator and a cardiologist at the University of Washington School of Medicine.   

JACC: Advances, a journal of the American College of Cardiology, published the paper today. Other co-senior authors are from Massachusetts General Hospital and the Broad Institute of MIT and Harvard.